Probing key DNA contacts in AraR-mediated transcriptional repression of the Bacillus subtilis arabinose regulon

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Probing key DNA contacts in AraR-mediated transcriptional repression of the Bacillus subtilis arabinose regulon

In the absence of arabinose, the AraR transcription factor represses the expression of genes involved in the utilization of arabinose, xylose and galactose in Bacillus subtilis. AraR exhibits a chimeric organization: the N-terminal DNA-binding region belongs to the GntR family and the C-terminal effector-binding domain is homologous to the GalR/LacI family. Here, the AraR-DNA-binding interactio...

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ژورنال

عنوان ژورنال: Nucleic Acids Research

سال: 2007

ISSN: 1362-4962,0305-1048

DOI: 10.1093/nar/gkm509